Publications

For a complete list, see Google scholar.

Selected publications

K. Kocher*, C. Moosmann*, F. Drost, C. Schülein, P. Irrgang, P. Steininger, J. Zhong, J. Träger, B. Spriewald, C. Bock, D. H. Busch, C. Bogdan, B. Schubert, T. H. Winkler, M. Tenbusch, E. M. Schuster*, K. Schober*, Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual. The Lancet Infectious Diseases. (2024) doi:10.1016/S1473-3099(24)00134-8

E. Dorigatti, F. Drost, A. Straub, P. Hilgendorf, K. I. Wagner, B. Bischl, D. H. Busch, K. Schober*, B. Schubert*. Predicting T cell receptor functionality against mutant epitopes, bioRxiv (2023), doi:10.1101/2023.05.10.540189.

A. Straub, S. Grassmann, S. Jarosch, L. Richter, P. Hilgendorf, M. Hammel, K. I. Wagner, V. R. Buchholz, K. Schober*, D. H. Busch*, Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon reinfection, Immunity (2023), doi:10.1016/j.immuni.2023.04.010.

P. Irrgang*, J. Gerling*, K. Kocher*, D. Lapuente, P. Steininger, K. Habenicht, M. Wytopil, S. Beileke, S. Schäfer, J. Zhong, G. Ssebyatika, T. Krey, V. Falcone, C. Schülein, A. S. Peter, K. Nganou-Makamdop, H. Hengel, J. Held, C. Bogdan, K. Überla, K. Schober*, T. H. Winkler*, M. Tenbusch*, Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination, Sci. Immunol. (2023), doi:10.1126/sciimmunol.ade2798.

E. Vogel*, K. Kocher*, A. Priller*, C.-C. Cheng*, P. Steininger, B.-H. Liao, N. Körber, A. Willmann, P. Irrgang, J. Held, C. Moosmann, V. Schmidt, S. Beileke, M. Wytopil, S. Heringer, T. Bauer, R. Brockhoff, S. Jeske, H. Mijocevic, C. Christa, J. Salmanton-García, K. Tinnefeld, C. Bogdan, S. Yazici, P. Knolle, O. A. Cornely, K. Überla, U. Protzer*, K. Schober*, M. Tenbusch*, Dynamics of humoral and cellular immune responses after homologous and heterologous SARS-CoV-2 vaccination with ChAdOx1 nCoV-19 and BNT162b2. eBioMedicine. (2022), doi: 10.1016/j.ebiom.2022.104294

A. Purcarea*, S. Jarosch*, J. Barton, S. Grassmann, L. Pachmayr, E. D'Ippolito, M. Hammel, A. Hochholzer, K. I. Wagner, J. H. van den Berg, V. R. Buchholz, J. B. A. G. Haanen, D. H. Busch*, K. Schober*, Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity. Sci. Immunol. (2022), doi:10.1126/sciimmunol.abm2077  (free access link)

C. Moosmann, T. R. Müller, D. H. Busch, K. Schober, Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair. STAR Protoc (2022), doi: 10.1016/j.xpro.2021.101031

D. S. Fischer*, M. Ansari*, K. I. Wagner*, S. Jarosch, Y. Huang, C. H. Mayr, M. Strunz, N. J. Lang, E. D. Ippolito, M. Hammel, L. Mateyka, S. Weber, L. S. Wolff, K. Witter, I. E. Fernandez, K. Milger, M. Frankenberger, L. Nowak, K. Heinig-Menhard, I. Koch, M. G. Stoleriu, A. Hilgendorff, J. Behr, A. Pichlmair, B. Schubert*, F. J. Theis*, D. H. Busch*, H. B. Schiller*, K. Schober*, Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through “reverse phenotyping.” Nat. Comm. (2021), doi:10.1038/s41467-021-24730-4

M. Hiltensperger, E. Beltrán, R. Kant, S. Tyystjärvi, G. Lepennetier, H. Domínguez Moreno, I. J. Bauer, S. Grassmann, S. Jarosch, K. Schober, V. R. Buchholz, S. Kenet, C. Gasperi, R. Öllinger, R. Rad, A. Muschaweckh, C. Sie, L. Aly, B. Knier, G. Garg, A. M. Afzali, L. A. Gerdes, T. Kümpfel, S. Franzenburg, N. Kawakami, B. Hemmer, D. H. Busch, T. Misgeld, K. Dornmair, T. Korn, Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nat. Immunol. (2021), doi:10.1038/s41590-021-00948-8.

M. Tenbusch*, S. Schumacher*, E. Vogel, A. Priller, J. Held, P. Steininger, S. Beileke, P. Irrgang, R. Brockhoff, J. Salmanton-García, K. Tinnefeld, H. Mijocevic, K. Schober, C. Bogdan, S. Yazici, P. Knolle, O. A Cornely*, Klaus Überla*, Ulrike Protzer* for the DZIF- VACCELERATE-CoVaKo study team. Heterologous prime–boost vaccination with ChAdOx1 nCoV-19 and BNT162b2. The Lancet Infectious Diseases. (2021), doi: 10.1016/ S1473-3099(21)00420-5

T. R. Müller, S. Jarosch, M. Hammel, J. Leube, S. Grassmann, B. Bernard, M. Effenberger, I. Andrae, M. Z. Chaudhry, T. Käuferle, A. Malo, L. Cicin-Sain, P. Steinberger, T. Feuchtinger, U. Protzer, K. Schumann, M. Neuenhahn, K. Schober*, D. H. Busch*, Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. Cell Rep Med (2021), doi: 10.1016/j.xcrm.2021.100374.

K. Schober*, F. Voit*, S. Grassmann, T. R. Müller, J. Eggert, S. Jarosch, B. Weißbrich, P. Hoffmann, L. Borkner, E. Nio, L. Fanchi, C. R. Clouser, A. Radhakrishnan, L. Mihatsch, P. Lückemeier, J. Leube, G. Dössinger, L. Klein, M. Neuenhahn, J. D. Oduro, L. Cicin-Sain, V. R. Buchholz, D. H. Busch, Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection. Nat. Immunol. 21, 434–441 (2020), doi:10.1038/s41590-020-0628-2

D. Stenger, T. A. Stief, T. Kaeuferle, S. Willier, F. Rataj, K. Schober, B. Vick, R. Lotfi, B. Wagner, T. G. P. Grünewald, S. Kobold, D. H. Busch, I. Jeremias, F. Blaeschke, T. Feuchtinger, Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR. Blood. 136, 1407–1418 (2020), doi:10.1182/blood.2020005185.

T. R. Müller, C. Schuler, M. Hammel, A. Köhler, S. Jutz, J. Leitner, K. Schober*, D. H. Busch*, P. Steinberger*, A T‐cell reporter platform for high‐throughput and reliable investigation of TCR function and biology. Clin. Transl. Immunol. 9, 1–16 (2020), doi:10.1002/cti2.1216.

S. Grassmann*, L. Mihatsch*, J. Mir, A. Kazeroonian, R. Rahimi, S. Flommersfeld, K. Schober, I. Hensel, J. Leube, L. O. Pachmayr, L. Kretschmer, Q. Zhang, A. Jolly, M. Z. Chaudhry, M. Schiemann, L. Cicin-Sain, T. Höfer, D. H. Busch, M. Flossdorf, V. R. Buchholz, Early emergence of T central memory precursors programs clonal dominance during chronic viral infection. Nat. Immunol. 21, 1563–1573 (2020), doi:10.1038/s41590-020-00807-y .

K. Schober*, T. R. Müller*, F. Gökmen, S. Grassmann, M. Effenberger, M. Poltorak, C. Stemberger, K. Schumann, T. L. Roth, A. Marson, D. H. Busch, Orthotopic replacement of T-cell receptor α- and β-chains with preservation of near-physiological T-cell function. Nat. Biomed. Eng. 3, 974–984 (2019), doi:10.1038/s41551-019-0409-0.

T. Hassler, E. Urmann, S. Teschner, C. Federle, T. Dileepan, K. Schober, M. K. Jenkins, D. H. Busch, M. Hinterberger, L. Klein, Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors. Proc. Natl. Acad. Sci. 116, 18537–18543 (2019), doi:10.1073/pnas.1907615116.

C. Schuster, K. D. Gerold, K. Schober, L. Probst, K. Boerner, M.-J. Kim, A. Ruckdeschel, T. Serwold, S. Kissler, The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. Immunity. 42, 942–952 (2015), doi:10.1016/j.immuni.2015.04.011.